قد يعاني المريض من بعض الآثار الجانبية الشائعة، مثل: الصداع، والغثيان، وسوء الهضم، وآلام العضلات، وفي بعض الحالات القليلة قد يحدث انخفاض ضغط الدم أو الإغماء، وهنا يجب طلب المساعدة الطبية فوراً.
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يجب أن يتحرك المريض ببطء عند الانتقال من مكان لآخر عند تناول دواء تادالافيل.
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يمنع استخدام التادالافيل دون استشارة الطبيب المختص في الحالات الآتية: